| Event | Time | Date | Name | Meet | History |
|---|---|---|---|---|---|
| 50 Free | 21.30 | March 16, 2023 | Gabi Albiero | NCAA Division I Womens Championship | |
| 100 Free | 46.20 | March 17, 2018 | Mallory Comerford | NCAA Division I Womens Championships | |
| 200 Free | 1:39.80 | March 16, 2018 | Mallory Comerford | NCAA Division I Womens Championships | |
| 500 Free | 4:34.63 | Feb. 21, 2019 | Mallory Comerford | Atlantic Coast Championships (W) | |
| 1000 Free | 9:33.23 | Jan. 14, 2022 | Liberty Williams | Louisville vs. Indiana | |
| 1650 Free | 15:43.21 | Feb. 19, 2022 | Liberty Williams | Atlantic Coast Championships | |
| 50 Back | 23.54 | Feb. 14, 2023 | Abby Hay | Atlantic Coast Championships | |
| 100 Back | 51.48 | March 18, 2022 | Abby Hay | NCAA Division I Womens Championship | |
| 200 Back | 1:51.70 | Feb. 18, 2023 | Paige Hetrick | Atlantic Coast Championships | |
| 50 Breast | 28.25 | Oct. 7, 2016 | Andrea Cottrell | Michigan vs. Louisville | |
| 100 Breast | 58.26 | Feb. 19, 2016 | Andrea Cottrell | Atlantic Coast Championships (W) | |
| 200 Breast | 2:06.90 | Feb. 16, 2017 | Andrea Cottrell | Atlantic Coast Championships (W) | |
| 50 Fly | 24.76 | Oct. 7, 2016 | Grace Oglesby | Michigan vs. Louisville | |
| 100 Fly | 49.43 | March 18, 2016 | Kelsi Dahlia | NCAA Division I Womens Championships | |
| 200 Fly | 1:50.61 | March 19, 2016 | Kelsi Dahlia | NCAA Division I Womens Championships | |
| 100 IM | 56.54 | Jan. 6, 2017 | Andrea Cottrell | Louisville vs. Missouri | |
| 200 IM | 1:54.03 | March 16, 2023 | Abby Hay | NCAA Division I Womens Championship | |
| 400 IM | 4:03.51 | March 20, 2015 | Tanja Kylliainen | NCAA Division I Womens Championships | |
| 200 Free Relay | 1:25.29 | Feb. 15, 2023 | Albiero, Regenauer, Dennis, Welch | Atlantic Coast Championships | |
| 400 Free Relay | 3:08.92 | Feb. 18, 2023 | Albiero, Regenauer, Dennis, Welch | Atlantic Coast Championships | |
| 800 Free Relay | 6:53.75 | March 14, 2018 | Cattermole, Comerford, OPENYSHEVA, Bradford-Feldman | NCAA Division I Womens Championships | |
| 200 Medley Relay | 1:34.23 | Feb. 14, 2023 | Hay, Viberg, Regenauer, Albiero | Atlantic Coast Championships | |
| 400 Medley Relay | 3:26.93 | March 15, 2018 | Kendzior, ASTASHKINA, Oglesby, Comerford | NCAA Division I Womens Championships |
