| Time | Date | Name | Meet |
|---|---|---|---|
| 46.20 | March 17, 2018 | Mallory Comerford | NCAA Division I Womens Championships |
| 46.35 | March 18, 2017 | Mallory Comerford | NCAA Division I Womens Championships |
| 46.75 | Feb. 16, 2017 | Mallory Comerford | Atlantic Coast Championships (W) |
| 47.30 | Feb. 20, 2016 | Kelsi Dahlia | Atlantic Coast Championships (W) |
| 47.71 | Feb. 21, 2015 | Kelsi Dahlia | Atlantic Coast Championships (W) |
| 48.18 | March 22, 2014 | Kelsi Dahlia | NCAA Division I Womens Championships |
| 48.29 | Feb. 22, 2014 | Kelsi Dahlia | American Conference Championships |
| 48.53 | Dec. 7, 2013 | Kelsi Dahlia | AT&T Winter National Championships |
| 48.60 | March 21, 2009 | Whitney Campbell | NCAA Division I Womens Championships |
| 49.31 | Nov. 14, 2008 | Whitney Campbell | Missouri @Louisville |
