| Time | Date | Name | Meet |
|---|---|---|---|
| 4:34.63 | Feb. 21, 2019 | Mallory Comerford | Atlantic Coast Championships (W) |
| 4:35.78 | Nov. 30, 2017 | Mallory Comerford | USA Swimming Winter National Championships |
| 4:36.16 | March 16, 2017 | Mallory Comerford | NCAA Division I Womens Championships |
| 4:37.47 | Feb. 14, 2017 | Mallory Comerford | Atlantic Coast Championships (W) |
| 4:37.64 | Oct. 14, 2016 | Mallory Comerford | SMU Classic |
| 4:38.01 | Feb. 18, 2016 | Mallory Comerford | Atlantic Coast Championships (W) |
| 4:41.20 | Nov. 20, 2015 | Mallory Comerford | Louisville Invitational |
| 4:44.54 | Feb. 19, 2015 | Andrea Kneppers | Atlantic Coast Championships (W) |
| 4:45.34 | Nov. 22, 2013 | Abbie Houck | Michigan Invitational |
| 4:46.02 | Nov. 16, 2012 | Abby Chin | Purdue Invitational |
| 4:47.39 | Dec. 2, 2010 | Lindsey Laporte | USA Swimming Short Course Nationals - College Results |
| 4:49.37 | Feb. 19, 2009 | Amanda Henleben | Big East Championships - Day Two - Finals |
| 4:56.26 | Nov. 7, 2008 | Amanda Henleben | West Virginia @Louisville |
