| Time | Date | Name | Meet |
|---|---|---|---|
| 49.43 | March 18, 2016 | Kelsi Dahlia | NCAA Division I Womens Championships |
| 49.81 | March 20, 2015 | Kelsi Dahlia | NCAA Division I Womens Championships |
| 50.17 | Feb. 20, 2015 | Kelsi Dahlia | Atlantic Coast Championships (W) |
| 50.91 | Dec. 5, 2014 | Kelsi Dahlia | AT&T Winter Nationals - College Results |
| 50.95 | March 21, 2014 | Kelsi Dahlia | NCAA Division I Womens Championships |
| 51.55 | March 1, 2013 | Kelsi Dahlia | Big East Conference Championships |
| 53.02 | Nov. 17, 2012 | Kelsi Dahlia | Purdue Invitational |
| 53.10 | Feb. 18, 2011 | Raine Thompson | Big East Conference Championships |
| 53.79 | Feb. 19, 2010 | Raine Thompson | Big East Championships |
| 53.98 | Feb. 20, 2009 | Raine Thompson | Big East Championships - Day Three - Finals |
| 55.06 | Dec. 5, 2008 | Raine Thompson | ConocoPhillips Short Course Championships |
| 55.62 | Nov. 7, 2008 | Nicole Landisch | West Virginia @Louisville |
