| Time | Date | Name | Meet |
|---|---|---|---|
| 4:49.49 | Feb. 15, 2023 | Mercedes Traba | SEC Championships |
| 4:54.28 | Nov. 16, 2017 | Saleh Peacock | Phil Hansel Invitational |
| 4:54.48 | Nov. 20, 2014 | Carrie Bencic | Georgia Tech Invitational |
| 4:55.51 | Feb. 19, 2014 | Kathryn Babbin | Southeastern Conference Championships |
| 4:57.45 | Nov. 22, 2013 | Carrie Bencic | Georgia Tech Invitational |
| 4:58.66 | Feb. 18, 2010 | Amilia Salce | Southeastern Conference Championships |
| 5:02.06 | Nov. 20, 2009 | Amilia Salce | Hilltopper Invitational |
| 5:05.26 | Nov. 6, 2009 | Erika Deardorf | Arkansas vs. Vanderbilt |
| 5:06.87 | Oct. 17, 2009 | Erika Deardorf | Vanderbilt vs. Southern Illinois |
| 5:12.30 | Oct. 10, 2009 | Erika Deardorf | Alabama vs. Centenary, Vanderbilt |
| 5:17.57 | Oct. 17, 2008 | Leigh-Ann Axt | Arkansas, Vanderbilt @Tennessee |
