| Time | Date | Name | Meet |
|---|---|---|---|
| 4:19.19 | Feb. 24, 2023 | Samantha Grenon | America East Conference Championships |
| 4:20.82 | Feb. 24, 2022 | Samantha Grenon | Northeast Conference Championships |
| 4:22.79 | Feb. 21, 2020 | Samantha Grenon | Northeast Conference Championships |
| 4:24.40 | Feb. 27, 2015 | Lauren Doerrman | Northeast Conference Championships |
| 4:24.53 | March 1, 2013 | Lauren Doerrman | Northeast Conference Championships |
| 4:31.47 | Feb. 18, 2011 | Molly Smith | Northeast Conference Championships |
| 4:31.51 | Feb. 27, 2010 | Molly Smith | ECAC Championships |
| 4:36.27 | Feb. 12, 2010 | Molly Smith | Northeast Conference Championships |
| 4:40.82 | Dec. 4, 2009 | Molly Smith | Harold Anderson Invitational |
| 4:43.15 | Feb. 28, 2009 | Jess Looney | ECAC Open Swimming & Divi |
| 5:04.94 | Feb. 13, 2009 | Margaret Dickinson | Northeast Conference Championships - Day Two - Finals |
