| Time | Date | Name | Meet |
|---|---|---|---|
| 4:51.17 | Feb. 15, 2024 | Makayla Pearce | America East Conference Championships |
| 4:51.75 | Feb. 28, 2013 | Taylor Debever | Northeast Conference Championships |
| 4:57.37 | Feb. 23, 2012 | Taylor Debever | Northeast Conference Championships |
| 5:01.22 | Feb. 25, 2011 | Taylor Debever | Eastern College Athletic Conference Championships |
| 5:11.34 | Feb. 17, 2011 | Kim Carballeira | Northeast Conference Championships |
| 5:11.81 | Dec. 4, 2009 | Molly Smith | Harold Anderson Invitational |
| 5:18.32 | Feb. 27, 2009 | Jess Looney | ECAC Open Swimming & Divi |
| 5:25.47 | Feb. 12, 2009 | Amy Howell | Northeast Conference Championships - Day One - Finals |
