| Time | Date | Name | Meet |
|---|---|---|---|
| 21.76 | Nov. 11, 2022 | Ruard Van Renen | SIU A3 Performance Invitational |
| 21.87 | March 4, 2020 | Adam Cernek | Mid-American Championships (M) |
| 22.17 | March 4, 2015 | Joao Facciotti | Mid-American Championships (M) |
| 22.76 | Nov. 22, 2013 | Till Pallmann | Missouri Invitational |
| 23.46 | Jan. 28, 2012 | Justin Wolfe | Southern Illinois vs. Western Kentucky |
| 23.68 | March 4, 2011 | Cesar Perez- Martinez | Mid-American Conference Mens Championships |
| 24.23 | Dec. 3, 2010 | Cesar Perez- Martinez | USA Swimming Short Course Nationals - College Results |
| 24.36 | Dec. 5, 2009 | Kyle Riekena | Missouri Invitational |
| 24.58 | Oct. 30, 2009 | Timothy Silkaitis | Southern Illinois vs. Washington (Mo) |
| 26.47 | Oct. 17, 2009 | Kyle Riekena | Kentucky vs. Arkansas, Cumberland, Southern Illinois |
