| Time | Date | Name | Meet |
|---|---|---|---|
| 2:11.88 | Jan. 27, 2023 | Olivia Herron | Missouri vs. Southern Illinois |
| 2:12.96 | April 16, 2021 | Mima Zaborska | Missouri Valley Conference Championships |
| 2:13.13 | March 26, 2021 | Mima Zaborska | ISU vs. SIU and Ball Stat |
| 2:13.28 | Feb. 20, 2021 | Mima Zaborska | Ball State vs. Southern Illino |
| 2:14.40 | Nov. 20, 2016 | Samantha Parsons | Louisville Invitational |
| 2:15.61 | Oct. 8, 2016 | Samantha Parsons | Missouri State Invitational |
| 2:17.37 | Feb. 19, 2011 | Kristin Geppert | Missouri Valley Conference Championships |
| 2:19.40 | Jan. 29, 2011 | Kristin Geppert | Western Kentucky vs. Southern Illinois |
| 2:19.57 | Feb. 13, 2010 | Kristin Geppert | Missouri Valley Conference Championships |
| 2:21.63 | Dec. 6, 2009 | Kristin Geppert | Missouri Invitational |
| 2:22.21 | Nov. 7, 2009 | Kristin Geppert | Southern Illinois vs. Illinois |
| 2:23.61 | Oct. 17, 2009 | Kristin Geppert | Vanderbilt vs. Southern Illinois |
| 2:23.81 | Feb. 14, 2009 | Keli Kramer | Missouri Valley Conference Championships - Day Three - Finals |
| 2:24.66 | Dec. 7, 2008 | Kristin Geppert | Missouri Invite |
