| Time | Date | Name | Meet |
|---|---|---|---|
| 47.31 | Feb. 21, 2020 | Marek OSINA | American Athletic Conference Championships |
| 47.38 | March 1, 2019 | Tristan Taylor | American Athletic Conference Championships |
| 47.54 | Feb. 20, 2015 | Fran Krznaric | American Conference Championships |
| 49.29 | Feb. 16, 2012 | Andre Smedstad | Conference USA Championships |
| 51.00 | Feb. 25, 2011 | Roman Sandler | Conference USA Championships |
| 51.13 | Feb. 27, 2009 | Miles Maximini | Conference USA Championships - Day Three - Finals |
| 51.86 | Jan. 17, 2009 | Roman Sandler | UMBC @ East Carolina |
| 52.29 | Nov. 20, 2008 | Hunter Mehaffey | Gamecock Invite |
| 53.31 | Oct. 11, 2008 | Roman Sandler | Xavier, East Carolina, West Virginia @Marshall |
