| Time | Date | Name | Meet |
|---|---|---|---|
| 52.13 | Feb. 25, 2022 | Daisy Platts | Mid-American Championships (W) |
| 52.39 | April 16, 2021 | Daisy Platts | Mid-American Women's Conference Championships |
| 52.42 | April 15, 2021 | Daisy Platts | Mid-American Women's Conference Championships |
| 52.65 | March 19, 2021 | Daisy Platts | NCAA Division I Women's Championships |
| 52.87 | Feb. 28, 2020 | Daisy Platts | Mid-American Championships (W) |
| 53.18 | March 1, 2019 | Daisy Platts | Mid-American Championships (W) |
| 53.68 | Dec. 1, 2018 | Daisy Platts | Zippy Invitational |
| 54.26 | Dec. 5, 2015 | Maya Skorupski | Zippy Invitational |
| 54.80 | Dec. 6, 2014 | Maria Galic | Eastern Michigan Invitational |
| 55.60 | Nov. 21, 2014 | Maya Skorupski | Georgia Tech Invitational |
| 55.68 | Nov. 8, 2014 | Estela Davis Ortiz | Oakland vs. Bowling Green State, Eastern Michigan |
| 55.79 | Feb. 21, 2009 | Sami Jordan | Mid-American Conference Championships - Day Three - Finals |
| 56.80 | Dec. 6, 2008 | Sami Jordan | Ohio State Invitational |
| 58.88 | Nov. 1, 2008 | Sami Jordan | Ball State @Bowling Green |
