| Time | Date | Name | Meet |
|---|---|---|---|
| 46.92 | Feb. 23, 2024 | Christopher Fabian | Patriot League Championships |
| 47.66 | Feb. 17, 2023 | Christopher Fabian | Patriot League Championships |
| 48.00 | Feb. 18, 2022 | Christopher Fabian | Patriot League Championships |
| 48.76 | March 1, 2014 | Michael Nicholson | Eastern College Athletic Conference Championships |
| 49.37 | Feb. 17, 2012 | Taylor Harris | Patriot League Championships |
| 49.94 | Feb. 20, 2009 | Michael Volpe | Patriot League Championships - Day Two - Finals |
| 50.60 | Nov. 22, 2008 | Taylor Harris | Bucknell Bison Invitational |
