| Time | Date | Name | Meet |
|---|---|---|---|
| 51.04 | March 21, 2015 | Veronika Jedryka | NCAA Division III Championships |
| 51.15 | Dec. 7, 2014 | Veronika Jedryka | MIT Invitational |
| 51.21 | Dec. 7, 2013 | Veronika Jedryka | MIT Invitational |
| 51.30 | March 24, 2012 | Anna Kokensparger | NCAA Division III Championships |
| 52.23 | Feb. 19, 2012 | Christy Rogers | New England Womens and Mens Athletics Conference Womens Championships |
| 52.24 | Feb. 21, 2010 | Amy Jacobi | New England Women's And Men's Conference Championships (W) |
| 52.77 | Nov. 21, 2009 | Anna Kokensparger | Bowdoin vs. Babson, MIT |
| 53.13 | March 15, 2008 | Sasha Brophy | NCAA Division III Womens Championship |
| 54.06 | March 11, 2006 | Sasha Brophy | NCAA Division III Womens Championships |
