| Time | Date | Name | Meet |
|---|---|---|---|
| 21.44 | March 17, 2022 | Grace Countie | NCAA Division I Womens Championship |
| 21.45 | Feb. 16, 2022 | Grace Countie | Atlantic Coast Championships |
| 21.48 | Nov. 30, 2017 | Caroline Baldwin | Tennessee Invitational |
| 21.78 | Feb. 14, 2017 | Caroline Baldwin | Atlantic Coast Championships (W) |
| 21.98 | Nov. 17, 2016 | Caroline Baldwin | NC State/GAC Invitational |
| 22.17 | Feb. 20, 2014 | Hannah Lincoln | Atlantic Coast Conference Championships (W) |
| 22.21 | March 17, 2011 | Rebecca Kane | NCAA Division I Womens Championships |
| 22.29 | Feb. 17, 2011 | Rebecca Kane | Atlantic Coast Conference Womens Championships |
| 22.41 | Feb. 19, 2009 | Rebecca Kane | Atlantic Coast Conference Championships (Women) - Day Two - Finals |
| 22.83 | March 20, 2008 | Kelsey Morrissy | NCAA Division I Womens Championships |
| 23.10 | March 8, 2007 | Kelsey Morrissy | NCAA Division I Womens Championships |
