| Time | Date | Name | Meet |
|---|---|---|---|
| 44.58 | March 29, 2024 | Tommy Janton | NCAA Division I Mens Championships |
| 44.99 | Feb. 23, 2024 | Tanner Filion | Atlantic Coast Championships |
| 45.12 | March 24, 2023 | Tommy Janton | NCAA Division I Mens Championships |
| 45.61 | Feb. 17, 2023 | Tommy Janton | Atlantic Coast Championships |
| 45.81 | March 8, 2020 | John Montesi | Men's Boiler-Make-It Qualification |
| 46.33 | March 1, 2019 | John Montesi | Atlantic Coast Championships (M) |
| 46.39 | March 22, 2018 | Rob Whitacre | NCAA Division I Mens Championships |
| 46.46 | Feb. 23, 2018 | Rob Whitacre | Atlantic Coast Championships (M) |
| 46.53 | March 1, 2017 | Rob Whitacre | Atlantic Coast Championships (M) |
| 47.17 | Feb. 28, 2014 | Matthew BUERGER | Atlantic Coast Conference Championships (M) |
| 47.80 | Dec. 6, 2013 | Bogac Ayhan | Iowa Invitational |
| 47.95 | Feb. 18, 2011 | Petar Petrovic | Big East Conference Championships |
| 48.64 | Feb. 19, 2010 | Petar Petrovic | Big East Championships |
| 48.96 | Dec. 5, 2009 | Petar Petrovic | Ohio State Invitational |
| 49.06 | Dec. 4, 2009 | Petar Petrovic | Ohio State Invitational |
| 49.60 | Feb. 20, 2009 | Mitchell Sherman | Big East Championships - Day Three - Finals |
