| Time | Date | Name | Meet |
|---|---|---|---|
| 50.08 | Feb. 22, 2024 | Lucas Jauregui | Liberty League Championships |
| 50.80 | Dec. 2, 2023 | Lucas Jauregui | Bomber Invitational |
| 51.01 | Feb. 16, 2022 | Max White | Liberty League Championships |
| 51.02 | Feb. 16, 2017 | Anthony Walker | UNYSCSA/Empire 8 Championships |
| 51.45 | Feb. 18, 2016 | Anthony Walker | UNYSCSA/Empire 8 Championships |
| 51.47 | Feb. 19, 2015 | Anthony Walker | UNYSCSA/Empire 8 Championships |
| 51.57 | Feb. 20, 2014 | Anthony Walker | UNYSCSA/Empire 8 Championships |
| 52.90 | Feb. 3, 2014 | Anthony Walker | Vassar Sprint Invitational |
| 53.53 | Nov. 16, 2013 | Anthony Walker | Rensselaer Polytechnic Institute vs. Vassar |
| 54.72 | Feb. 24, 2011 | Mathue Duhaney | Empire 8 / UNYSCSA Championships |
| 55.42 | Feb. 27, 2010 | Mathue Duhaney | Upper New York State Collegiate Swimming Association Championships |
| 56.79 | Dec. 5, 2009 | Mathue Duhaney | Liberty League Championships |
| 57.28 | Nov. 22, 2008 | John Alaimo | Vassar @SUNY-New Paltz |
