| Time | Date | Name | Meet |
|---|---|---|---|
| 52.77 | April 20, 2024 | Sarah Blake | Shawnee Mission Invitational |
| 52.80 | May 19, 2023 | Sarah Blake | KSHSAA Girls 6A State Championships |
| 52.86 | May 20, 2022 | Caroline Blake | KSHSAA Girls 6A State Championships |
| 53.00 | May 17, 2019 | Caroline Blake | Kansas 6A Girls State Championship |
| 54.25 | May 18, 2018 | Olivia Vance | Kansas 6A Girls State Championship |
| 54.30 | May 22, 2015 | Grace Brimacombe | Kansas Girls 6A High School Championships |
| 54.77 | May 23, 2014 | Grace Brimacombe | Kansas Girls 1-5A High School Championships |
| 55.20 | May 19, 2011 | Mardi Buchanan | Kansas Girls 1-6A High School Championships |
