| Name | Time | Date | Meet |
|---|---|---|---|
| Nikola Tadic | 45.97 | Feb. 24, 2023 | IHSA Boys State Championship |
| Konner Scott | 45.99 | March 1, 2011 | 2010-11 Illinois Boys High School Best Times |
| Konner Scott | 47.32 | Feb. 27, 2009 | 2008-09 Illinois Boys State Championships |
| Alex Babin | 49.70 | Feb. 27, 2004 | 2004 IHSA Boys State Championships |
