| Time | Date | Name | Meet |
|---|---|---|---|
| 3:59.18 | Feb. 17, 2023 | Joe Nadur | Ohio Athletic Conference Championships |
| 3:59.49 | Nov. 18, 2022 | Joe Nadur | Kenyon Total Performance Invitational |
| 4:02.72 | March 26, 2021 | Jonathan Simoes | Ohio Athletic Conference Championships |
| 4:03.38 | Feb. 14, 2020 | Nick Mudry | - |
| 4:03.38 | Feb. 14, 2020 | Nick Mudry | Ohio Athletic Conference Championships |
| 4:07.70 | Nov. 17, 2018 | Erik Sriubas | Wabash College Invitational |
| 4:12.51 | Oct. 27, 2018 | Erik Sriubas | John Carroll vs. Ohio Northern |
| 4:13.96 | Feb. 16, 2018 | Colin Burke | Ohio Athletic Conference Championships |
| 4:14.76 | Feb. 17, 2017 | Ben Parker | Ohio Athletic Conference Championships |
| 4:18.44 | Dec. 4, 2016 | Ben Parker | Fredonia Blue Devil Invitational |
| 4:19.25 | Feb. 19, 2016 | Ben Parker | Ohio Athletic Conference Championships |
| 4:21.30 | Feb. 14, 2014 | Michael Goggins | Ohio Athletic Conference Championships |
| 4:22.83 | Feb. 18, 2011 | Brendan Carey | Ohio Athletic Conference Championships |
| 4:23.07 | Feb. 19, 2010 | Brendan Carey | Ohio Athletic Conference Championships |
| 4:41.18 | Jan. 17, 2009 | Brendan Carey | John Carroll & Allegheny @Oberlin |
| 4:50.79 | Oct. 25, 2008 | Brendan Carey | Ohio Northern @John Carroll |
