| Event | Time | Date | Name | Meet | History |
|---|---|---|---|---|---|
| 50 Free | 18.89 | March 23, 2023 | Van Mathias | NCAA Division I Mens Championships | |
| 100 Free | 41.16 | March 24, 2018 | Blake Pieroni | NCAA Division I Mens Championships | |
| 200 Free | 1:29.63 | March 21, 2018 | Blake Pieroni | NCAA Division I Mens Championships | |
| 500 Free | 4:10.87 | March 23, 2017 | Marwan ELKAMASH | NCAA Division I Mens Championships | |
| 1000 Free | 8:51.20 | Jan. 14, 2022 | Michael Brinegar | Louisville vs. Indiana | |
| 1650 Free | 14:27.50 | March 30, 2019 | Michael Brinegar | NCAA Division I Mens Championships | |
| 50 Back | 20.60 | March 22, 2023 | Brendan Burns | NCAA Division I Mens Championships | |
| 100 Back | 43.61 | March 24, 2023 | Brendan Burns | NCAA Division I Mens Championships | |
| 200 Back | 1:38.18 | March 30, 2024 | Brendan Burns | NCAA Division I Mens Championships | |
| 50 Breast | 26.39 | Jan. 27, 2023 | Jack Kimmelshue | Louisville vs. Indiana | |
| 100 Breast | 49.69 | March 23, 2018 | Ian Finnerty | NCAA Division I Mens Championships | |
| 200 Breast | 1:49.90 | March 30, 2019 | Ian Finnerty | NCAA Division I Mens Championships | |
| 50 Fly | 22.63 | March 9, 2023 | Chris Holmes | CSCAA National Invitational Championships | |
| 100 Fly | 43.85 | March 29, 2024 | Tomer Frankel | NCAA Division I Mens Championships | |
| 200 Fly | 1:38.71 | March 26, 2022 | Brendan Burns | NCAA Division I Mens Championship | |
| 100 IM | 49.17 | March 16, 2019 | Thomas Vanderbrook | CSCAA National Invitational Time Trials | |
| 200 IM | 1:40.23 | March 28, 2019 | Vinicius Lanza | NCAA Division I Mens Championships | |
| 400 IM | 3:40.64 | March 28, 2014 | Stephen Schmuhl | NCAA Division I Mens Championships | |
| 200 Free Relay | 1:15.41 | March 28, 2019 | Apple, BLASKOVIC, Samy, Hamblin | NCAA Division I Mens Championships | |
| 400 Free Relay | 2:47.11 | March 24, 2018 | Hassan, Pieroni, BLASKOVIC, Khalafalla | NCAA Division I Mens Championships | |
| 800 Free Relay | 6:06.01 | March 21, 2018 | Pieroni, Hassan, Lanza, Finnerty | NCAA Division I Mens Championships | |
| 200 Medley Relay | 1:21.52 | March 22, 2023 | Burns, Mathias, Frankel, Wight | NCAA Division I Mens Championships | |
| 400 Medley Relay | 2:59.09 | March 24, 2023 | Burns, Matheny, Frankel, Miroslaw | NCAA Division I Mens Championships |
