| Time | Date | Name | Meet |
|---|---|---|---|
| 4:10.39 | Feb. 27, 2020 | Zachary Yeadon | Atlantic Coast Championships (M) |
| 4:12.74 | Feb. 22, 2018 | Zachary Yeadon | Atlantic Coast Championships (M) |
| 4:14.93 | Nov. 17, 2017 | Zachary Yeadon | Ohio State Invitational |
| 4:17.13 | March 27, 2014 | Frank Dyer | NCAA Division I Mens Championships |
| 4:17.49 | March 28, 2013 | Frank Dyer | NCAA Division I Mens Championships |
| 4:17.97 | March 22, 2012 | Frank Dyer | NCAA Division I Mens Championships |
| 4:18.50 | Feb. 16, 2012 | Frank Dyer | Big East Conference Championships |
| 4:19.08 | Feb. 17, 2011 | Frank Dyer | Big East Conference Championships |
| 4:23.99 | Feb. 19, 2009 | Steven Brus | Big East Championships - Day Two - Finals |
| 4:28.82 | Dec. 5, 2008 | Steven Brus | Ohio State Invitational |
