| Time | Date | Name | Meet |
|---|---|---|---|
| 46.13 | Feb. 26, 2016 | En-Wei Hu-Van Wright | Ivy League Championships (M) |
| 46.43 | Dec. 5, 2015 | En-Wei Hu-Van Wright | Big Al Open |
| 46.47 | Feb. 27, 2015 | Michael Strand | Ivy League Championships (M) |
| 46.68 | Dec. 6, 2013 | Michael Strand | Big Al Invitational |
| 47.04 | March 2, 2012 | Michael Strand | Ivy League Mens Championships |
| 47.88 | March 1, 2012 | Kaspar Raigla | Ivy League Mens Championships |
| 48.11 | March 4, 2011 | Kaspar Raigla | Ivy League Men's Championships |
| 48.43 | March 4, 2010 | Kaspar Raigla | Ivy League Men's Championships |
| 48.69 | March 26, 2009 | Doug Lennox | NCAA Division I Mens Championships |
| 48.85 | Jan. 31, 2009 | Doug Lennox | Princeton, Yale @Harvard |
| 49.07 | March 3, 2005 | James Zee | EISL Championships |
| 49.52 | Feb. 28, 2002 | Patrick Donohue | Men's EISL Championships |
