| Time | Date | Name | Meet |
|---|---|---|---|
| 50.39 | Feb. 24, 2018 | Katie Lafferty | Northeast Conference Championships |
| 50.61 | Feb. 25, 2012 | Alicia Ford | Northeast Conference Championships |
| 51.03 | Feb. 19, 2011 | Alicia Ford | Northeast Conference Championships |
| 52.52 | Dec. 4, 2010 | Alicia Ford | USA Swimming Short Course National Championships |
| 52.53 | Feb. 13, 2010 | Elise Merrill | Northeast Conference Championships |
| 53.80 | Jan. 16, 2010 | Hanna Yttring | St. Francis (PA) vs. Youngstown State |
| 53.96 | Oct. 17, 2009 | Alicia Ford | St. Francis (PA) vs. Cleveland State |
| 54.39 | Feb. 14, 2009 | Elise Merrill | Northeast Conference Championships - Day Three - Finals |
| 54.44 | Nov. 21, 2008 | Elise Merrill | Youngstown State Invitational |
| 54.89 | Nov. 8, 2008 | Melissa Heintz | Thomas Murphy Invitational |
