| Name | Time | Date | Meet |
|---|---|---|---|
| Ruard Van Renen | 46.10 | March 3, 2023 | Mid-American Championships (M) |
| Joao Facciotti | 47.02 | March 4, 2016 | 2016 Mid-American Championships (M) |
| Justin Wolfe | 47.29 | March 2, 2012 | Mid-American Conference Mens Championships |
| Justin Wolfe | 47.92 | Nov. 17, 2011 | Tennessee Invitational |
| Justin Wolfe | 47.95 | Nov. 20, 2010 | Purdue Invitational |
| Justin Wolfe | 48.41 | Feb. 20, 2009 | 2009 Sun Belt Conference Championships - Day Two - Finals |
| Anthony Bousquet | 49.13 | Dec. 6, 2008 | 2008 Mizzou Invitational |
| Justin Wolfe | 51.32 | Nov. 7, 2008 | Missouri @Southern Illinois |
