| Time | Date | Name | Meet |
|---|---|---|---|
| 2:17.20 | April 10, 2021 | Ella Kerr | Horizon League Championships |
| 2:18.09 | March 2, 2013 | Sami Roberts | Horizon League Championships |
| 2:18.52 | Feb. 26, 2011 | Sami Roberts | Horizon League Championships |
| 2:24.76 | Nov. 12, 2010 | Sami Roberts | Youngstown State vs. Bowling Green |
| 2:26.76 | Nov. 6, 2010 | Sami Roberts | Marshall vs. Youngstown State |
| 2:28.46 | Jan. 16, 2010 | Sami Roberts | St. Francis (PA) vs. Youngstown State |
| 2:29.04 | Nov. 7, 2008 | Olivia Arnold | Niagra & Youngstown State @Cleveland State |
