| Event | Time | Date | Name | Meet | History |
|---|---|---|---|---|---|
| 50 Free | 21.98 | Nov. 18, 2021 | Missy Cundiff | WVU Invitational | |
| 100 Free | 48.37 | Feb. 25, 2023 | Katie Stevenson | Colonial Athletic Association Championships | |
| 200 Free | 1:45.73 | March 17, 2023 | Katie Stevenson | NCAA Division I Womens Championship | |
| 500 Free | 4:44.62 | Feb. 21, 2019 | Megan Bull | Colonial Athletic Association Championships | |
| 1000 Free | 9:57.65 | March 2, 2013 | Caylyn Tate | - | |
| 1650 Free | 16:36.86 | Feb. 27, 2016 | Morgan Smith | Colonial Athletic Association Championships | |
| 50 Back | 25.37 | Feb. 27, 2013 | Gabrielle Mizerak | Colonial Athletic Association Championships | |
| 100 Back | 53.71 | Feb. 26, 2016 | Sophie Rittenhouse | Colonial Athletic Association Championships | |
| 200 Back | 1:56.16 | Feb. 25, 2017 | Sophie Rittenhouse | Colonial Athletic Association Championships | |
| 50 Breast | 29.40 | Nov. 16, 2018 | Ellie Henry | Northwestern TYR Invitational | |
| 100 Breast | 1:00.84 | March 1, 2024 | Ellie Scherer | Coastal Athletic Association Championships | |
| 200 Breast | 2:13.25 | March 2, 2024 | Ellie Scherer | Coastal Athletic Association Championships | |
| 50 Fly | 25.03 | Nov. 7, 2014 | Megan Howard | William and Mary vs. Duke | |
| 100 Fly | 52.70 | Nov. 17, 2023 | Sophia Heilen | WVU Invitational | |
| 200 Fly | 1:57.03 | Nov. 19, 2022 | Sophia Heilen | WVU Invitational | |
| 100 IM | 59.54 | Nov. 6, 2016 | Jess Crowley | William & Mary vs. Delaware, East Carolina | |
| 200 IM | 1:58.38 | Nov. 16, 2023 | Sophia Heilen | WVU Invitational | |
| 400 IM | 4:19.34 | Feb. 24, 2012 | Brodde Lamb | - | |
| 400 IM | 4:19.34 | Feb. 24, 2012 | Brodde Lamb | Colonial Athletic Association Championships | |
| 200 Free Relay | 1:30.95 | Feb. 23, 2017 | Miller, Miller, Herold, Sell | Colonial Athletic Association Championships | |
| 400 Free Relay | 3:19.41 | Feb. 25, 2023 | Stevenson, Heilen, Burgeson, Querner | Colonial Athletic Association Championships | |
| 800 Free Relay | 7:12.67 | Feb. 28, 2009 | - | ||
| 200 Medley Relay | 1:38.53 | Feb. 22, 2023 | Vanbourgondien, Scherer, Heilen, Stevenson | Colonial Athletic Association Championships | |
| 400 Medley Relay | 3:19.19 | Feb. 27, 2009 | - |
