| Name | Time | Date | Meet |
|---|---|---|---|
| Ale SENIS | 4:16.87 | Feb. 29, 2024 | Big XII Conference Championships |
| Megan Morris | 4:17.72 | Feb. 26, 2021 | Big XII Conference Championships |
| Alison Bleasdell | 4:18.21 | March 1, 2013 | 2013 Big 12 Conference Championships |
| Ashley Bolin | 4:18.35 | Feb. 25, 2011 | Mountain West Conference Championships |
| Ashley Bolin | 4:26.73 | Nov. 7, 2008 | Colorado State @Texas Christian |
