| Time | Date | Name | Meet |
|---|---|---|---|
| 45.64 | Feb. 21, 2020 | Gustavo Santos | American Athletic Conference Championships |
| 45.83 | March 10, 2019 | Gustavo Santos | Tar Heel Last Chance Meet Marc |
| 45.86 | March 1, 2019 | Gustavo Santos | American Athletic Conference Championships |
| 45.89 | Feb. 25, 2018 | Gustavo Santos | Liberty University Last Chance Meet |
| 46.82 | Feb. 16, 2018 | Gustavo Santos | American Conference Championships |
| 47.07 | Feb. 17, 2017 | Gustavo Santos | American Conference Championships |
| 48.06 | Feb. 22, 2013 | Daniel Woods | Conference USA Championships |
| 48.53 | Feb. 17, 2012 | Daniel Woods | Conference USA Championships |
| 49.00 | Feb. 27, 2009 | Andrew Stoker | Conference USA Championships - Day Three - Finals |
| 50.62 | Nov. 20, 2008 | Junior Temotio | Gamecock Invite |
| 51.12 | Oct. 11, 2008 | Andrew Stoker | Xavier, East Carolina, West Virginia @Marshall |
