| Time | Date | Name | Meet |
|---|---|---|---|
| 21.69 | Feb. 19, 2020 | Marek OSINA | American Athletic Conference Championships |
| 21.81 | Feb. 21, 2013 | Andre Smedstad | Conference USA Championships |
| 23.04 | Feb. 15, 2012 | Andre Smedstad | Conference USA Championships |
| 23.72 | Nov. 18, 2011 | Andre Smedstad | North Carolina Invitational |
| 23.75 | Feb. 23, 2011 | Attila Kiraly | Conference USA Championships |
| 23.89 | Feb. 24, 2010 | Roman Sandler | Conference USA Championships |
| 24.41 | Oct. 24, 2009 | Roman Sandler | East Carolina vs. Campbell, Marshall, Towson |
| 24.77 | Oct. 8, 2009 | Roman Sandler | East Carolina vs. North Carolina |
