| Time | Date | Name | Meet |
|---|---|---|---|
| 1:25.17 | Feb. 14, 2024 | Gallob, Kelly, Burke, Jyawook | Horizon League Championships |
| 1:25.88 | Feb. 15, 2023 | Burke, Kelly, Jyawook, Wickens | Horizon League Championships |
| 1:26.72 | Feb. 16, 2022 | Burke, Kelly, Jyawook, Wickens | Horizon League Championships |
| 1:27.66 | Feb. 19, 2020 | Lohse, Hahs, Burke, Jung | Horizon League Championships |
| 1:28.82 | Feb. 17, 2016 | Brysch, Mintch, Stoller, Kuester | Summit League Championships |
| 1:29.84 | Feb. 18, 2015 | Carroll, Mintch, Stoller, Kuester | Summit League Championships |
| 1:30.69 | Feb. 19, 2014 | Carroll, Mintch, Ferguson, Kuester | Summit League Championships |
| 1:32.77 | Nov. 23, 2013 | Carroll, Mintch, Ferguson, Kuester | House of Champions Invitational |
| 1:33.85 | Nov. 9, 2013 | Carroll, Mintch, Ferguson, Kuester | IUPUI vs. Wright St |
| 1:34.87 | Feb. 20, 2013 | Saunders, Ferguson, Lunte, Hamilton | Summit League Championships |
| 1:34.99 | Feb. 15, 2012 | Carroll, Ferguson, Van Dyke, Hamilton | Summit League Championships |
| 1:38.26 | Oct. 15, 2011 | Carroll, Ferguson, Van Dyke, Howard | Indiana Intercollegiates |
| 1:38.44 | Feb. 21, 2009 | Summit League Championships - Day Two - Finals | |
| 1:40.78 | Nov. 14, 2008 | Xavier, St. Louis, UW-Milwaukee @IUPUI | |
| 1:41.88 | Oct. 17, 2008 | Butler, Centre @ IUPUI |
