| Time | Date | Name | Meet |
|---|---|---|---|
| 45.66 | Feb. 21, 2018 | Landis Hollingsworth | Horizon League Championships |
| 49.73 | Feb. 19, 2016 | Aaron Brysch | Summit League Championships |
| 50.24 | Feb. 20, 2015 | Aaron Brysch | Summit League Championships |
| 50.75 | Feb. 22, 2013 | Tony Carroll | Summit League Championships |
| 51.47 | Nov. 30, 2012 | Tony Carroll | House of Champions Invite |
| 51.98 | Feb. 17, 2012 | Tony Carroll | Summit League Championships |
| 52.67 | Feb. 18, 2011 | Hunter Chiasson | Summit League Championships |
| 52.92 | Jan. 20, 2011 | Tony Carroll | IUPUI vs. Saint Louis, Xavier, Western Illinois |
| 53.29 | Feb. 19, 2010 | Michael Steurer | Summit League Championships |
| 53.30 | Feb. 18, 2010 | Michael Steurer | Summit League Championships |
| 53.73 | Feb. 21, 2009 | Michael Steurer | Summit League Championships - Day Two - Finals |
| 55.07 | Nov. 14, 2008 | Michael Steurer | Xavier, St. Louis, UW-Milwaukee @IUPUI |
