| Event | Time | Date | Name | Meet | History |
|---|---|---|---|---|---|
| 50 Free | 22.55 | March 31, 2009 | Karen Balko | - | |
| 100 Free | 50.35 | Feb. 18, 2017 | Maranda Buha | Summit League Championships | |
| 200 Free | 1:47.10 | Feb. 14, 2024 | Emmaleigh Zietlow | Horizon League Championships | |
| 500 Free | 4:44.88 | Nov. 17, 2022 | Emmaleigh Zietlow | House of Champions Invitational | |
| 1000 Free | 10:07.90 | Jan. 13, 2023 | Emmaleigh Zietlow | Oakland vs. IUPUI vs. Youngstown State | |
| 1650 Free | 16:25.95 | Feb. 17, 2024 | Emmaleigh Zietlow | Horizon League Championships | |
| 50 Back | 25.16 | Feb. 21, 2018 | Mallory Buha | Horizon League Championships | |
| 100 Back | 54.66 | Feb. 15, 2019 | Mallory Buha | Horizon League Championships | |
| 200 Back | 1:57.90 | Jan. 21, 2023 | Emmaleigh Zietlow | IUPUI vs. Wabash (M) | |
| 50 Breast | 29.50 | Jan. 21, 2023 | Avery Brooks | IUPUI vs. Wabash (M) | |
| 100 Breast | 1:02.95 | April 9, 2021 | Aubrey Wing | Horizon League Championships | |
| 200 Breast | 2:16.65 | Feb. 21, 2015 | Jennifer Oleksiak | Summit League Championships | |
| 50 Fly | 24.64 | Jan. 22, 2022 | Caylee Hamilton | IUPUI vs. Valparaiso | |
| 100 Fly | 53.50 | Feb. 15, 2019 | Mallory Buha | Horizon League Championships | |
| 200 Fly | 2:01.86 | Jan. 21, 2023 | Gabrielle Puryear-Lynch | IUPUI vs. Wabash (M) | |
| 100 IM | 58.68 | Oct. 28, 2022 | Emma Theobald | Milwaukee vs. IUPUI | |
| 200 IM | 2:01.31 | March 14, 2024 | Emmaleigh Zietlow | CSCAA National Invitational Championship | |
| 400 IM | 4:16.59 | Feb. 17, 2023 | Emma Theobald | Horizon League Championships | |
| 200 Free Relay | 1:33.07 | Feb. 18, 2016 | Buha, Bullard, Taylor, Kroon | Summit League Championships | |
| 400 Free Relay | 3:23.24 | Feb. 16, 2019 | Buha, Kroon, Hanas, Ronci | Horizon League Championships | |
| 800 Free Relay | 7:19.47 | Feb. 15, 2023 | Zietlow, Puryear-Lynch, Theobald, Bontrager | Horizon League Championships | |
| 200 Medley Relay | 1:41.18 | Feb. 19, 2020 | Thompson, Wing, Bruce, Snyder | Horizon League Championships | |
| 400 Medley Relay | 3:44.53 | Feb. 15, 2019 | Bruce, Wing, Buha, Ronci | Horizon League Championships |
