| Time | Date | Name | Meet |
|---|---|---|---|
| 3:54.60 | March 16, 2018 | Ella Eastin | NCAA Division I Womens Championships |
| 3:56.53 | Feb. 23, 2018 | Katie Ledecky | Pacific 12 Championships (W) |
| 3:57.57 | March 17, 2017 | Ella Eastin | NCAA Division I Womens Championships |
| 3:57.68 | Feb. 24, 2017 | Katie Ledecky | Pacific 12 Championships (W) |
| 3:58.12 | March 21, 2014 | Maya DiRado | NCAA Division I Womens Championships |
| 3:58.21 | Oct. 17, 2008 | Julia Smit | Florida, Stanford @Michigan |
| 4:02.41 | March 21, 2008 | Julia Smit | NCAA Division I Womens Championships |
| 4:06.10 | March 9, 2007 | Julia Smit | NCAA Division I Womens Championships |
