| Time | Date | Name | Meet |
|---|---|---|---|
| 45.56 | March 18, 2017 | Simone Manuel | NCAA Division I Womens Championships |
| 46.09 | March 21, 2015 | Simone Manuel | NCAA Division I Womens Championships |
| 46.62 | Nov. 22, 2014 | Simone Manuel | Art Adamson Invitational |
| 47.17 | March 22, 2014 | Lia Neal | NCAA Division I Womens Championships |
| 47.44 | March 21, 2009 | Julia Smit | NCAA Division I Womens Championships |
| 48.67 | Oct. 17, 2008 | Kate Dwelley | Florida, Stanford @Michigan |
| 48.87 | March 10, 2007 | Brooke Bishop | NCAA Division I Womens Championships |
