| Time | Date | Name | Meet |
|---|---|---|---|
| 4:06.93 | March 28, 2024 | Luke Hobson | NCAA Division I Mens Championships |
| 4:07.37 | March 23, 2023 | Luke Hobson | NCAA Division I Mens Championships |
| 4:08.19 | March 28, 2019 | Townley Haas | NCAA Division I Mens Championships |
| 4:08.42 | March 23, 2017 | Clark Smith | NCAA Division I Mens Championships |
| 4:08.82 | Dec. 3, 2015 | Clark Smith | Texas Hall of Fame Swimming Invitational |
| 4:09.32 | March 26, 2009 | Michael Klueh | NCAA Division I Mens Championships |
| 4:10.00 | March 27, 2008 | Michael Klueh | NCAA Division I Mens Championships |
| 4:13.75 | Jan. 1, 2007 | Michael Klueh | Indiana, Texas @Michigan |
| 4:14.10 | Feb. 15, 2006 | Michael Klueh | NCAA Division I Mens Championships |
| 4:18.63 | March 6, 2003 | Chris Kemp | American Short Course Championships |
